![]() Tap on the “Reset” option and then tap “Erase All Content and Settings”.Here’s how you can reinstall from the Recovery Mode. ![]() You need to wait and reach your PC to set up the device. If you don’t want to lose your data, we suggest using iTunes. In addition, all your settings will return to the default state. This method will eventually delete all your data stored on your iPhone or iPad. In that case, you can clean reinstall without a PC. It could be possible that you aren’t currently at your setup and can’t reinstall iOS using a PC. Previous methods require a Mac or PC to restore the iPhone/iPad. Wait for the iOS to reset and reinstall again. Once the process is done, your device will reboot.įortunately, there is another way to reset your iPhone or iPad and clean install iOS software again.Click on “Restore” to begin reinstalling the iOS software.Connect the iPhone or iPad to your PC. Once you do this, iTunes will show a prompt asking you to restore your iPhone or iPad.Keep holding the Home button until you get a reminder about connecting your iPhone to iTunes to enter the Recovery Mode.Hold the Home button and connect your iPhone to your Mac or PC simultaneously.Here’s how you can enter into Recovery Mode and reinstall iOS software. You need to enter the Recovery Mode and follow a few simple steps. You can use this method if your iPhone isn’t rebooting or the previous method doesn’t work for you. It is the best way to reset your device when you can’t do it normally. Similar to Android or Mac Recovery Mode, iPhones and iPad also have built-in Recovery Mode. Select “Agree” to let iTunes reset your iPhone/iPad until then, you need to wait.Click the “Restore and Update” button to confirm reinstalling the iOS.Move to the “Software” section and click “Restore iPhone”.Select the “Backup now” option to start taking a backup of your current device.Check the “Encrypt local backup” checkbox.Click “Backup all of the data on your iPhone/iPad to this Mac/PC” to create a backup.Select your iPhone or iPad on the sidebar.Launch the iTunes app on your Mac or PC.Enter the passcode to unlock your iPhone and tap on “Trust”. ![]()
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Zoom desktop client for Windows, macOS, or Linux: Global minimum version or higher Bandwidth requirements.Version 3.9 is compatible with Mac OSX version 10.8 (Mountain Lion) and up.This article is part of the Source-Connect Standard 3.9 User Guide Minimum System Support Version 3.9.x - Mac OSX ![]() ![]() Kunti and Madri accompany Pandu to the forest. On Shakuni’s advise, Dhritrashtra take the throne. Gandhari got pregnant, and Pandu leaves his throne. While hunting in the Forest, Pandu mistakenly kills Rishi Kindam and his wife, on which he curses him. Dhritrashtra decides to mend his relationship with Gandhari. He wins the war and returns to Hastinapur with his second wife, Madri. Kunti tells the truth of Karna to Pandu, and Pandu leaves for the war. Karna, who is the first son of Kunti (unaware of this fact), welcomes Kunti and Pandu in Hastinapur.įrustrated Dhritrashtra blames Pandu for conspiring against him for the throne. Pandu becomes the king of Hastinapur by Bhishma and married to Kunti. Dhritrashtra desperately wanted to become a king to hide his disability, but Vidur advises Bheem not to do so. Dhritrashtra marries Gandhari for the betterment of Hastinapur but later humiliates and rejects her as his wife for her oath. Shakuni gets upset after learning about this offer and Gandhari takes an oath to blindfold herself for a lifetime to support her husband. In season 2, Bhishma asks King Subala to marry his daughter Gandhari with Dhritrashtra and offer him Hastinapur in return. Lord Shiva agrees and Amba reborn as Shikhandi, daughter of King Drupad. Amba asks rebirth from Shiva to take revenge on Bhishma. To stop the battle between Parshuram and Bhishma, Lord Shiva interferes. ![]() Bhishma meets Parshuram who orders him to fight. Amba returns to Hastinapur and asks Bhishma to choose between marriage or death. On Satyawati’s demand, Ambika and Ambalika get pregnant by Vyasa and give birth to Dhritrashtra (Blind son of Ambika), Vidur and Pandu (Son of Ambalika). Meanwhile, Vichitravirya married to Ambika and Ambalika, but as he is about to become the King, he dies. Amba seeks Parshuram for help but in vain. Amba refuses to marry as she is committed towards King Salva.īut after the abduction of Amba by Bhishma, Salva refuses to marry her, and as a justice, Amba asks Bhishma to marry her, which he denies. ![]() Later, Satyawati sends Bhishma to the king of Kashi to seek his daughters Amba, Ambalika and Ambika as brides for Vichitravirya. For her happiness, Bhishma refuses the crown, and Satywati’s son Vichitravirya is to be crowned king. Shantanu announces Bhishma, the prince of Hastinapur and Bhishma request Satywati to live with them, which she refuses. When Satyawati learns about Bhishma and Ganga, she leaves Shantanu. Shantanu, the king of Hastinapur, gets to know from Ganga that they have a son named Bhishma. The first season of Mahabharat revolves around Ganga, Shantanu, his wife Satyawati and their sons. Based on the greatest battle of Kauravas and Pandavas for the thrown, and Wisdom Lesson of Krishna, this show comprises of the total 28 seasons and 269 episodes. Because of its content and cast, the show has become the highest-rated weekday mythological show. Star Channel spent 120 Crores on the production and marketing of this Indian Mythological show Mahabharata. Also Check: Ramayan & Mahabharat Return Inspired Memers to Make Memes on Netflix, & Amazon Prime Video Episode & Season Details Of Mahabharat (2013) ![]() ![]() ![]() So, this approach has the advantage of being completely unbiased but its big downside is that you don’t have any prior understanding of the biology and even after you find some active molecules, it is still very hard to elucidate their mechanism of action and molecular targets. You don’t know the target and you are not betting on one. An alternative approach is phenotypic screening and there, you basically screen many molecules and look for those that reverse the phenotype. So, this betting on a target is a real problem and for many diseases, we are still in the dark with regards to what is the real cause and do not understand the full biology. The target that was chosen is the “secret switch” to turn off the disease phenotype. When drugs fail in the clinic it is mainly because we do not understand the disease mechanism. The problem here is that you are betting on the target to have an effect on disease phenotype. The first approach is to come up with a proposed target and screen against that protein. For a very long time, companies had to choose between two very different approaches to drug discovery. This elucidation of underlying disease biology is now happening at the beginning of a drug discovery process, rather than being tried at the end of it. We pinpoint the disease mechanism and then apply our mRNA knowledge graph and our mRNA biology LLM, an augmented large language model that we built around mRNA knowledge. We feed them to our AI mRNA Image Neural Network which has been trained on over 2 billion such images, proprietary data that came from our projects across a decade. ![]() What we are doing at Anima is applying our proprietary mRNA biology visualisation technologies to generate millions of images of mRNA regulatory pathways in disease models. So, as you can see, AI has the potential to completely transform the process by visualising and decoding disease biology.Ĭan you elaborate on how Anima’s unique approach to visualising the entire life cycle of mRNA in cells is revolutionising our understanding of diseases and potential treatments? You can then screen molecule libraries to find modulators of the underlying disease biology. This is where I see things going: using AI to process vast amounts of data coming through images taken from live biology of a disease model, identify what is causing the disease, the disease signature, and then have AI suggest targets along that pathway. You could then use large language models to research all available knowledge around that pathway and novel drug targets. It would see in the images the pathway that tells the diseased cells apart from the healthy ones, essentially elucidating the disease mechanism. So, you could capture images of live mRNA biology from millions of diseased and healthy cells and have an AI neural network trained to recognise the differences. We could use it to identify the underlying disease mechanism, the dysregulated pathway, or as we call it at Anima, the “disease signature”.ĪI has become very capable in both understanding and generating images. ![]() The elucidation, or “decoding” of complex biology is becoming possible with AI’s ability to process large amounts of visual data and recognise patterns in images. And this is exactly where AI can provide us with an extremely powerful new strategy. And since mRNA biology is like the highway of cell biology, it would likely be visible there. And really, this comes to the biggest question of all: what is the underlying mechanism of a given disease? There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype. However, our inability to understand that biology is what stands in the way of further progress. All of these are novel targets to be explored in small molecule drug discovery as well as for improving the efficacy of mRNA vaccines. Examples of such mechanisms include RBPs, splicing, and relocalisation of mRNAs among many others. Complex regulatory pathways move mRNAs through their life cycles and control when, where, and how much of each individual protein is made. mRNA is an intermediate form that codes the instructions for making proteins but the biology around its regulation is not well understood and is still an “uncracked code”. RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. MRNA biology has become widely recognised as a new “drug mine”. Where do you see the future of mRNA biology and AI converging, and how does Anima Biotech plan to lead this convergence? ![]() ![]() ![]() "This Bookish Sweater Has a Violent History". ![]() ^ le Zotte, Jennifer (3 October 2017).Department of labor, Bureau of labor statistics. ^ Consumer Price Index Apparel Manual.The Cardigans are a Swedish rock band formed in 1992, best known for the singles " Lovefool" and " My Favourite Game".Singer-songwriter Taylor Swift wrote a song called " Cardigan" and used cardigans as part of her merchandise accompanying the song and her eighth studio album, Folklore (2020).It was reported to have a burn hole, a button missing, and discoloration around the pockets. The sweater he wore during MTV's Nirvana Unplugged concert sold at auction for $137,500 in November 2015. Kurt Cobain of the band Nirvana wore vintage cardigans. ![]() Steve McQueen popularised cardigans, wearing it in the 1968 action thriller film Bullitt and in his personal life.The cardigans were made by his mother and closed with a zipper instead of buttons. Fred Rogers, star of the long-running children's program Mister Rogers' Neighborhood, donned a cardigan at the beginning of each episode.The trademark sweaters complemented his easy-going style of singing. Singer Perry Como wore cardigans on the television program The Perry Como Show.Varsity letters for college and high school sports teams have been applied to cardigans and letterman jackets. A less formal style is wearing a T-shirt underneath. As an item of formal clothing for any gender, it is worn over a button-down dress shirt. Monochromatic cardigans, in sleeved or vest form, may be viewed as a conservative fashion staple. Its versatility means it can be worn in casual or formal settings and in any season, but it is most popular during cool weather. Plain cardigans are often worn over shirts and inside suit jackets as a less formal version of the waistcoat or vest that restrains the necktie when the jacket has been removed. Coco Chanel is credited with popularizing cardigans for women because "she hated how tight-necked men's sweaters messed up her hair when she pulled them over her head." The garment is mostly associated with the college culture of the Roaring Twenties and early 1930s, being also popular throughout the 1950s, 1970s, 1990s, 2000s and into the early 2010s. The term originally referred only to a knitted sleeveless vest, but expanded to other types of garment over time. The legend of the event and the fame that Lord Cardigan achieved after the war led to the rise of the garment's popularity – supposedly, Brudenell invented the cardigan after noticing that the tails of his coat had accidentally been burnt off in a fireplace. It is modelled after the knitted wool waistcoat that British officers supposedly wore during the war. The cardigan was named after James Brudenell, 7th Earl of Cardigan, a British Army major general who led the Charge of the Light Brigade at the Battle of Balaclava during the Crimean War. Traditionally, cardigans were made of wool but can now be made of cotton, synthetic fibers, or any combination thereof. By contrast, a pullover (or sweater) does not open in front but must be "pulled over" the head to be worn. A current fashion trend has the garment with no buttons or zipper and hangs open by design. Knit garments with zippers can also be referred to as a cardigan. Description A baggy cardigan A tightly fitting cardigan with a blouseĬommonly cardigans are open fronted, have buttons, and are often knitted or woven: garments that are tied are instead considered a robe. A cardigan is a type of knitted sweater that has an open front, and is worn like a jacket. ![]() ![]() ![]() ![]() politicians have developed deep ties with platforms like Facebook. Whether and how to regulate social media is a political question, but many U.S. There is effectively no regulation for social media companies they change only in pursuit of profits or to minimize public outcry. ![]() Time-delays took hold in TV only because broadcasting regulators penalized broadcasters for airing inappropriate content during live shows. Facebook could even let people request a company moderator for upcoming livestreams.įacebook has not yet taken this relatively simple step – and the reason is clear. Major users, including publishers and corporations, could be permitted to livestream directly after completing a training course. Only then would enough adult users have screened it and had the chance to report its content. That time allows a moderator to review the content and confirm that it’s appropriate for a broad audience.įacebook relies on users as moderators, and some livestreams may not have a large audience like TV, so its delay would need to be longer, perhaps a few minutes. In the television industry, short time-delays of a few seconds are typical during broadcasts of live events. They also suggest that people don’t know how to report inappropriate content – or don’t have confidence the company will act on the complaint.įacebook founder and CEO Mark Zuckerberg discusses the murder of Robert Godwin Sr. These details make painfully clear how dependent Facebook is on users to flag harmful content. The company recently issued some analytic details and noted that fewer than 200 people viewed the livestream of the massacre, and that surprisingly, no users reported it to Facebook until after it ended. Facebook highlighted the fact that 1.2 million of them “ were blocked at upload.” However, as a social media researcher and educator, I heard that as an admission that 300,000 videos and images of a mass murder passed through its automated systems and were visible on the platform. In the 24 hours after the New Zealand massacre, 1.5 million videos and images of the killings were uploaded to Facebook’s servers, the company announced. Though the company has hired more than 3,000 additional human content moderators, Facebook is not any better at keeping horrifying violence from streaming live online without any filter or warning for users. Facebook Live has broadcast killings, as well as other serious crimes such as sexual assault, torture and child abuse. That way, adult users would have an opportunity to flag inappropriate content before children were exposed to it. In the wake of Godwin’s murder, I recommended that Facebook Live broadcasts be time-delayed, at least for Facebook users who had told the company they were under 18. Facebook later clarified that the graphic video was uploaded after the event, but the incident called public attention to the risks of livestreaming violence. In 2017, Godwin was murdered in Cleveland, Ohio, and initial reports indicated that the attacker streamed it on Facebook Live, at the time a relatively new feature of the social network. When word broke that the massacre in New Zealand was livestreamed on Facebook, I immediately thought of Robert Godwin Sr. ![]() |
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